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CAS No.: 168626-94-6
Synonyms: YM 087;Conivaptan (hydrochloride);盐酸考尼伐坦
Conivaptan HCl is an inhibitor of antidiuretic hormone or antagonist of vasopressin receptor. It can inhibit rat liver V1A receptor and kidney V2 receptor with Ki of 0.48 nM and 3.04 nM, respectively.
生物活性
靶点 | Vasopressin Receptor 2A (rat kidney) Ki:3.04nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00811486 | Right Heart Failure ... more >> Pulmonary Hypertension Collapse << | Not Applicable | Withdrawn(Only 1 patient recru... more >>ited, and he withdrew) Collapse << | - | United States, Colorado ... more >> University of Colorado at Denver and Health Sciences Center General Clinical Research Center Denver, Colorado, United States, 80262 Collapse << |
NCT01954290 | Acute Cerebrovascular Accident... more >> Cerebral Edema Collapse << | Phase 2 | Withdrawn(Investigator is leav... more >>ing the institution.) Collapse << | - | - |
NCT00380575 | Hyponatremia | Phase 3 | Completed | - | - |
实验方案
技术信息
CAS号 | 168626-94-6 | 储存条件 |
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分子式 | C32H27ClN4O2 | 运输 | 蓝冰 | |||||||
分子量 | 535.04 | 别名 | YM 087;Conivaptan (hydrochloride);盐酸考尼伐坦 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00811486 | Right Heart Failure ... more >> Pulmonary Hypertension Collapse << | Not Applicable | Withdrawn(Only 1 patient recru... more >>ited, and he withdrew) Collapse << | - | United States, Colorado ... more >> University of Colorado at Denver and Health Sciences Center General Clinical Research Center Denver, Colorado, United States, 80262 Collapse << |
NCT01954290 | Acute Cerebrovascular Accident... more >> Cerebral Edema Collapse << | Phase 2 | Withdrawn(Investigator is leav... more >>ing the institution.) Collapse << | - | - |
NCT00380575 | Hyponatremia | Phase 3 | Completed | - | - |
NCT00492037 | Hyponatremia | Phase 3 | Completed | - | Belgium ... more >> Bruxelles, Belgium Liege, Belgium Tournai, Belgium Finland Jyväskylä, Finland Turku, Finland France Garches, France Limoges, France Paris Cedex 10, France Germany Bad Nauheim, Germany Berlin, Germany Dresdan, Germany Göttingen, Germany Munchen, Germany Italy Ferrara, Italy Pavia, Italy Pisa, Italy Verona, Italy Netherlands Delft, Netherlands Groningen, Netherlands Leiden, Netherlands Nijmegen, Netherlands Poland Radomsko, Poland Warsaw, Poland Wroclaw, Poland Spain Barcelona, Spain Cordoba, Spain Madrid, Spain United Kingdom Cardiff, United Kingdom Manchester, United Kingdom Collapse << |
NCT00379847 | Hyponatremia | Phase 3 | Completed | - | United States, Arizona ... more >> Tuscon, Arizona, United States, 85723 United States, Colorado Denver, Colorado, United States, 80262 United States, District of Columbia Washington, District of Columbia, United States, 20007 United States, Georgia Augusta, Georgia, United States, 30901 United States, Michigan Petoskey, Michigan, United States, 49700 United States, Ohio Cincinnati, Ohio, United States, 45219 United States, South Carolina Columbia, South Carolina, United States, 29209 Israel Afula, Israel Ashkelon, Israel Hadera, Israel 2 Sites Haifa, Israel Holon, Israel 2 Sites Jerusalem, Israel Nahariya, Israel Rechovot, Israel 2 Sites Safed, Israel Tel-Aviv, Israel Zerifin, Israel South Africa Amanzimototi, South Africa Bellville, South Africa Bloemfontein, South Africa 2 Sites Durban, South Africa 4 Sites Johannesburg, South Africa Krugersdorp, South Africa Lyttelton, South Africa Pretoria, South Africa Somerset West, South Africa Soweto, South Africa Collapse << |
NCT00592475 | Liver Cirrhosis | Phase 2 | Completed | - | Spain ... more >> Barcelona, Spain Collapse << |
NCT00057356 | Chronic Heart Failure | Phase 2 | Completed | - | - |
NCT00684164 | Hyponatremia | Phase 3 | Withdrawn(Unable to complete a... more >> contract with the Sponsor) Collapse << | June 2010 | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
NCT00435591 | - | - | Completed | - | - |
NCT00843986 | Hyponatremia ... more >>Acute Decompensated Heart Failure Collapse << | Phase 3 | Terminated(The clinical study ... more >>has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.) Collapse << | - | India ... more >> Hyderabaad, India, 500063 Karnal, India, 132001 New Delhi, India, 110025 New Delhi, India, 110060 Collapse << |
NCT00592475 | - | - | Completed | - | - |
NCT00924014 | Heart Failure | Not Applicable | Unknown | March 2010 | United States, Minnesota ... more >> Hennepin county Medical Center Not yet recruiting Minneapolis, Minnesota, United States, 55404 Principal Investigator: Steven R Goldsmith, MD Collapse << |
NCT00930202 | Severe Traumatic Brain Injury | Phase 1 | Completed | - | United States, Washington ... more >> Harborview Medical Center Seattle, Washington, United States, 98104 Collapse << |
NCT00806910 | Heart Failure | Phase 4 | Withdrawn(Sponsor support with... more >>drawn) Collapse << | - | - |
NCT00435591 | Hyponatremia ... more >>Euvolemia Hypervolemia Collapse << | Phase 4 | Completed | - | United States, South Carolina ... more >> Charleston, South Carolina, United States, 29425 India Bangalore, India, 560034 Bangalore, India, 560099 Bhopal, India, 462001 Hyderabaad, India, 500482 Karnal, India, 132001 Israel Afula, Israel, 18101 Ashkelon, Israel, 78308 Haifa, Israel, 31048 Haifa, Israel, 34362 Holon, Israel, 58100 Jerusalem, Israel, 910301 Jerusalem, Israel, 91120 Rechovot, Israel, 76100 Safed, Israel, 13100 Tel Hashomer, Israel, 52621 Tel-Aviv, Israel, 64239 Zerifin, Israel, 70300 Collapse << |
NCT00727090 | - | - | Terminated(Enrollment below go... more >>al.) Collapse << | - | - |
NCT00478192 | - | - | Completed | - | - |
NCT00727090 | Hyponatremia | Phase 4 | Terminated(Enrollment below go... more >>al.) Collapse << | - | - |
NCT01451411 | Hyponatremia | Phase 3 | Terminated(Enrollment goals we... more >>re not met.) Collapse << | - | United States, New York ... more >> Children's Hospital of New York - Presbyterian New York, New York, United States, 10032 Colombia Fundación Cardioinfantil - Instituto Cardiológico Bogota, Colombia Fundación Valle del Lili Cali, Valle, Colombia Collapse << |
NCT00478192 | Hyponatremia | Phase 3 | Completed | - | - |
NCT01451411 | - | - | Terminated(Enrollment goals we... more >>re not met.) Collapse << | - | - |
NCT01370148 | Liver Disease | Phase 1 | Completed | - | United States, California ... more >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Colorado DaVita Clinical Research Lakewood, Colorado, United States, 80228 United States, Florida Orlando Clinical Research Orlando, Florida, United States, 32809 Collapse << |
NCT01752543 | Heart Failure | Phase 4 | Completed | - | Denmark ... more >> Department of Cardiology, Copenhagen University Hospital, Rigshospital Copenhagen, Denmark, 2100 Collapse << |
NCT03000283 | Cerebral Hemorrhage ... more >> Cerebral Edema Intracerebral Hemorrhage Stroke Collapse << | Not Applicable | Enrolling by invitation | January 2020 | United States, Minnesota ... more >> United Hospital Saint Paul, Minnesota, United States, 55102 Collapse << |
NCT00843986 | - | - | Terminated(The clinical study ... more >>has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.) Collapse << | - | - |
NCT00887627 | Kidney Diseases ... more >> Hyponatremia Collapse << | Phase 1 | Completed | - | United States, California ... more >> Anaheim, California, United States, 92801 Collapse << |
NCT00851227 | Liver Disease ... more >> Hyponatremia Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Miami, Florida, United States, 33014 Collapse << |
NCT00811486 | Right Heart Failure ... more >> Pulmonary Hypertension Collapse << | Not Applicable | Withdrawn(Only 1 patient recru... more >>ited, and he withdrew) Collapse << | - | United States, Colorado ... more >> University of Colorado at Denver and Health Sciences Center General Clinical Research Center Denver, Colorado, United States, 80262 Collapse << |
NCT00380575 | Hyponatremia | Phase 3 | Completed | - | - |
NCT00492037 | Hyponatremia | Phase 3 | Completed | - | Belgium ... more >> Bruxelles, Belgium Liege, Belgium Tournai, Belgium Finland Jyväskylä, Finland Turku, Finland France Garches, France Limoges, France Paris Cedex 10, France Germany Bad Nauheim, Germany Berlin, Germany Dresdan, Germany Göttingen, Germany Munchen, Germany Italy Ferrara, Italy Pavia, Italy Pisa, Italy Verona, Italy Netherlands Delft, Netherlands Groningen, Netherlands Leiden, Netherlands Nijmegen, Netherlands Poland Radomsko, Poland Warsaw, Poland Wroclaw, Poland Spain Barcelona, Spain Cordoba, Spain Madrid, Spain United Kingdom Cardiff, United Kingdom Manchester, United Kingdom Collapse << |
NCT00592475 | Liver Cirrhosis | Phase 2 | Completed | - | Spain ... more >> Barcelona, Spain Collapse << |
NCT00379847 | Hyponatremia | Phase 3 | Completed | - | United States, Arizona ... more >> Tuscon, Arizona, United States, 85723 United States, Colorado Denver, Colorado, United States, 80262 United States, District of Columbia Washington, District of Columbia, United States, 20007 United States, Georgia Augusta, Georgia, United States, 30901 United States, Michigan Petoskey, Michigan, United States, 49700 United States, Ohio Cincinnati, Ohio, United States, 45219 United States, South Carolina Columbia, South Carolina, United States, 29209 Israel Afula, Israel Ashkelon, Israel Hadera, Israel 2 Sites Haifa, Israel Holon, Israel 2 Sites Jerusalem, Israel Nahariya, Israel Rechovot, Israel 2 Sites Safed, Israel Tel-Aviv, Israel Zerifin, Israel South Africa Amanzimototi, South Africa Bellville, South Africa Bloemfontein, South Africa 2 Sites Durban, South Africa 4 Sites Johannesburg, South Africa Krugersdorp, South Africa Lyttelton, South Africa Pretoria, South Africa Somerset West, South Africa Soweto, South Africa Collapse << |
NCT00435591 | Hyponatremia ... more >>Euvolemia Hypervolemia Collapse << | Phase 4 | Completed | - | United States, South Carolina ... more >> Charleston, South Carolina, United States, 29425 India Bangalore, India, 560034 Bangalore, India, 560099 Bhopal, India, 462001 Hyderabaad, India, 500482 Karnal, India, 132001 Israel Afula, Israel, 18101 Ashkelon, Israel, 78308 Haifa, Israel, 31048 Haifa, Israel, 34362 Holon, Israel, 58100 Jerusalem, Israel, 910301 Jerusalem, Israel, 91120 Rechovot, Israel, 76100 Safed, Israel, 13100 Tel Hashomer, Israel, 52621 Tel-Aviv, Israel, 64239 Zerifin, Israel, 70300 Collapse << |
NCT01954290 | Acute Cerebrovascular Accident... more >> Cerebral Edema Collapse << | Phase 2 | Withdrawn(Investigator is leav... more >>ing the institution.) Collapse << | - | - |
NCT00684164 | Hyponatremia | Phase 3 | Withdrawn(Unable to complete a... more >> contract with the Sponsor) Collapse << | June 2010 | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
NCT00057356 | Chronic Heart Failure | Phase 2 | Completed | - | - |
NCT00924014 | Heart Failure | Not Applicable | Unknown | March 2010 | United States, Minnesota ... more >> Hennepin county Medical Center Not yet recruiting Minneapolis, Minnesota, United States, 55404 Principal Investigator: Steven R Goldsmith, MD Collapse << |
NCT00843986 | Hyponatremia ... more >>Acute Decompensated Heart Failure Collapse << | Phase 3 | Terminated(The clinical study ... more >>has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.) Collapse << | - | India ... more >> Hyderabaad, India, 500063 Karnal, India, 132001 New Delhi, India, 110025 New Delhi, India, 110060 Collapse << |
NCT00806910 | Heart Failure | Phase 4 | Withdrawn(Sponsor support with... more >>drawn) Collapse << | - | - |
NCT00592475 | - | - | Completed | - | - |
NCT00930202 | Severe Traumatic Brain Injury | Phase 1 | Completed | - | United States, Washington ... more >> Harborview Medical Center Seattle, Washington, United States, 98104 Collapse << |
NCT01451411 | Hyponatremia | Phase 3 | Terminated(Enrollment goals we... more >>re not met.) Collapse << | - | United States, New York ... more >> Children's Hospital of New York - Presbyterian New York, New York, United States, 10032 Colombia Fundación Cardioinfantil - Instituto Cardiológico Bogota, Colombia Fundación Valle del Lili Cali, Valle, Colombia Collapse << |
NCT00435591 | - | - | Completed | - | - |
NCT00478192 | - | - | Completed | - | - |
NCT00843986 | - | - | Terminated(The clinical study ... more >>has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.) Collapse << | - | - |
NCT01370148 | Liver Disease | Phase 1 | Completed | - | United States, California ... more >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Colorado DaVita Clinical Research Lakewood, Colorado, United States, 80228 United States, Florida Orlando Clinical Research Orlando, Florida, United States, 32809 Collapse << |
NCT00727090 | Hyponatremia | Phase 4 | Terminated(Enrollment below go... more >>al.) Collapse << | - | - |
NCT01752543 | Heart Failure | Phase 4 | Completed | - | Denmark ... more >> Department of Cardiology, Copenhagen University Hospital, Rigshospital Copenhagen, Denmark, 2100 Collapse << |
NCT00478192 | Hyponatremia | Phase 3 | Completed | - | - |
NCT00727090 | - | - | Terminated(Enrollment below go... more >>al.) Collapse << | - | - |
NCT00851227 | Liver Disease ... more >> Hyponatremia Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Miami, Florida, United States, 33014 Collapse << |
NCT00887627 | Kidney Diseases ... more >> Hyponatremia Collapse << | Phase 1 | Completed | - | United States, California ... more >> Anaheim, California, United States, 92801 Collapse << |
NCT01451411 | - | - | Terminated(Enrollment goals we... more >>re not met.) Collapse << | - | - |
NCT03000283 | Cerebral Hemorrhage ... more >> Cerebral Edema Intracerebral Hemorrhage Stroke Collapse << | Not Applicable | Enrolling by invitation | January 2020 | United States, Minnesota ... more >> United Hospital Saint Paul, Minnesota, United States, 55102 Collapse << |
靶点 | Description | IC50 |
---|---|---|
Vasopressin Receptor 2A (rat kidney) | Ki:3.04nM |
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